Golcadomide

Artikelnummer	Größe	Manual	Lieferzeit	Preis
Cay44114-1	1 mg	-	6 - 10 Werktage*	246,00 €
Cay44114-5	5 mg	-	6 - 10 Werktage*	674,00 €
Cay44114-10	10 mg	-	6 - 10 Werktage*	1.102,00 €

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Golcadomide is a cereblon (CRBN) E3 ligase modulator (CELMoD). It decreases protein levels of... mehr

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Produktinformationen "Golcadomide"

Golcadomide is a cereblon (CRBN) E3 ligase modulator (CELMoD). It decreases protein levels of Ikaros family zinc finger protein 1 (IKZF1) and IFN regulatory factor 4 (IRF4) in JSC-1, BCBL-1, Daudi, and BL-41 lymphoma cells when used at a concentration of 0. µM and decreases the viability of these cells in a concentration-dependent manner. Golcadomide (0. µM) increases the levels of intracellular adhesion molecule-1 (ICAM-1) and CD86 in Daudi, Raji, and Epstein-Barr virus-positive BL-41 cells. InChI: InChI=1S/C28H30FN5O5/c29-21-12-17(14-32-15-19(16-32)33-8-10-39-11-9-33)4-5-18(21)13-30-22-3-1-2-20-25(22)28(38)34(27(20)37)23-6-7-24(35)31-26(23)36/h1-5,12,19,23,30H,6-11,13-16H2,(H,31,35,36)/t23-/m0/s1 InChIKey: NZYDBVQXOGPDDU-QHCPKHFHSA-N SMILES: FC(C=C(C=C1)CN2CC(N3CCOCC3)C2)=C1CNC4=C5C(C(N([C@@H]6C(NC(CC6)=O)=O)C5=O)=O)=CC=C4

Schlagworte:	CC-99282, 2-[(3S)-2,6-dioxo-3-piperidinyl]-4-[[[2-fluoro-4-[[3-(4-morpholinyl)-1-azetidinyl]methyl]phenyl]methyl]amino]-1H-isoindole-1,3(2H)-dione
Hersteller:	Cayman Chemical
Hersteller-Nr:	44114

Eigenschaften

Anwendung:	Cereblon modulator, CELMoD, antineoplastic, thalidomide derivative
MW:	535.58 D
Formel:	C28H30FN5O5
Reinheit:	>98%
Format:	Solid

Datenbank Information

CAS :	2379572-34-4\| Passende Produkte
KEGG ID :	K11793 \| Passende Produkte

Handhabung & Sicherheit

Lagerung:	-20°C
Versand:	+20°C (International: -20°C)
Signalwort:	Warning
GHS-Piktogramme:
H-Sätze:	H302, H315, H319
P-Sätze:	P264, P270, P280, P301+310, P302+352, P305+351+338, P321, P330, P332+313, P337+313, P362+364, P501