GNE-6640

Description: GNE-6640 is a non-covalent inhibitor targeting ubiquitin specific peptidase 7 (USP7), exhibiting IC50 values of 0.75 µM for full-length USP7, 0.43 µM for the USP7 catalytic domain, 20.3 µM for full-length USP43, and 0.23 µM for Ub-MDM2, respectively. Target: DUB. Smiles: CCc1c(cnc(N)c1-c1ccc(O)cc1)-c1ccc2[nH]ncc2c1. References: Kategaya L, et al. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 2017 Oct 26,550(7677):534-538.