GNE-493

Description: GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kalpha, PI3Kbeta, PI3Kdelta, PI3Kgamma and mTOR,respectively. Target: mTOR, PI3K. Smiles: CC(C)(O)c1cc2nc(nc(N3CCOCC3)c2s1)-c1cnc(N)nc1. References: Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer[J]. Journal of Medicinal Chemistry, 2010, 53(3):1086-1097.