GNE-131

An inhibitor of Nav1.7 (IC50 = 0.003 µM), selective for Nav1.7 over Nav1.1, Nav1.2, Nav1.5, and Nav1.6 (IC50s = 0.045, 0.007, 0.110, and 0.092 µM, respectively), reduces aconitine-induced nocifensive behavior in a transgenic mouse model of IEM at 30 mg/kg. SMILES: O=[S](NC1=NN=C2C=C(C(C3CC3)=CN21)OCC4(C[C@@H](C5)C6)C[C@@H]6C[C@@H]5C4)(C7CC7)=O. InChi Code: InChI=1S/C23H30N4O3S/c28-31(29,18-3-4-18)26-22-25-24-21-8-20(19(12-27(21)22)17-1-2-17)30-13-23-9-14-5-15(10-23)7-16(6-14)11-23/h8,12,14-18H,1-7,9-11,13H2,(H,25,26)/t14-,15+,16-,23?. InChi Key: FPERPEQIXLOVIK-QUXYOMGYSA-N