Zu "K04841" wurden 49 Artikel gefunden!
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Bupivacaine
Artikelnummer: Cay16618-500
Bupivacaine is a sodium channel blocker and local anesthetic. It inhibits sodium currents in rat dorsal horn neurons in a concentration-dependent manner and inhibits synaptic transmission in rat sympathetic ganglia, increasing the firing threshold when used at a concentration of 200 nM. Bupivacaine (10 µM) blocks...
| Schlagworte: | 1-butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide |
| Anwendung: | Sodium influx blocker |
| CAS | 38396-39-3 |
| MW: | 288.4 D |
ab 49,00 €
NaV1.7 - HEK293 recombinant human stable cell line...
Artikelnummer: BPS-60507
Nav1.7 (Genbank # Q15858) is present at the endings of pain-sensing nerves, the nociceptors, close to region where the impulse is initiated. The Nav1.7 channel produces a rapidly activating and inactivating current which is sensitive to level of tetrodotoxin. Knockout mice that lack Nav1.7 in nociceptors showed...
| Schlagworte: | PN1, NENA, hNE-Na, Peripheral sodium channel 1, Neuroendocrine sodium channel, Sodium channel protein type 9 subunit... |
| Anwendung: | Drug screening, functional assays |
14.330,00 €
PF-05089771 (tosylate)
Artikelnummer: Cay24449-5
PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50s = 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8 channels (IC50s = 0.11-25 µM), L-type calcium, and KvLQT and hERG potassium channels (IC50s =...
| Schlagworte: | 4-[2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolyl-4-benzenesulfonamide,... |
| Anwendung: | Nav1.7 blocker |
| CAS | 1430806-04-4 |
| MW: | 672.6 D |
ab 146,00 €
Nav1.7 Blocker 52
Artikelnummer: Cay34477-5
Nav1.7 blocker 52 is an inhibitor of voltage-gated sodium channel 1.7 (Nav1.7, IC50 = 0.17 µM). It is selective for Nav1.7 over human-ether-a-go-go (hERG), also known as Kv11.1, Nav1.5, and Nav1.8 (IC50s = >10, 1.1, and 2.2 µM, respectively) but does inhibit Nav1.3 and Nav1.4 (IC50s = 0.3 and 0.4 µM, respectively)....
| Schlagworte: | TC-N 1752, Voltage-gated Sodium Channel 1.7,... |
| Anwendung: | Nav1.7 inhibitor |
| CAS | 1211866-85-1 |
| MW: | 516.5 D |
ab 147,00 €
Carbamazepine
Artikelnummer: Cay15422-5
Carbamazepine is an inhibitor of sodium channels. It preferentially inhibits inactivated voltage-gated sodium channel Nav1.7 and Nav1.3 (IC50s = 406 and 900 µM, respectively) over resting (closed) Nav1.7 and Nav1.3 channels in whole-cell patch-clamp assays using HEK293 cells (IC50s = 1,584 and 2,464 µM,...
| Schlagworte: | CBZ, NSC 169864, 5H-dibenz[b,f]azepine-5-carboxamide |
| Anwendung: | Voltage-gated sodium channel blocker |
| CAS | 298-46-4 |
| MW: | 236.3 D |
ab 40,00 €
Anti-Nav1.7 Na+ Channel, clone S68-6
Artikelnummer: ARG56140.50
Protein function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical...
| Schlagworte: | Anti-PN1, Anti-NENA, Anti-hNE-Na, Anti-Peripheral sodium channel 1, Anti-Neuroendocrine sodium channel, Anti-Sodium... |
| Anwendung: | IHC (paraffin), WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | hamster, human, mouse, rat |
699,00 €
Anti-NAV1.7, clone S68-6
Artikelnummer: 200-301-G21
Anti-NAV1.7 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with NAV1.7 from Human, Rat, and Mouse based on 100% homology with the immunizing sequence. No cross-reactivity against other Nav channels. Cross-reactivity with NAV1.7 from other sources has not been...
| Schlagworte: | Anti-PN1, Anti-NENA, Anti-SCN9A, Anti-hNE-Na, Anti-Peripheral sodium channel 1, Anti-Neuroendocrine sodium channel,... |
| Anwendung: | IHC, IFM, IP, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
752,00 €
Anti-SCN9A
Artikelnummer: E-AB-16052.120
This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. Protein function: Mediates the voltage-dependent...
| Schlagworte: | Anti-PN1, Anti-NENA, Anti-hNE-Na, Anti-Peripheral sodium channel 1, Anti-Neuroendocrine sodium channel, Anti-Sodium... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 89,00 €
Benzonatate
Artikelnummer: Cay23936-1
Benzonatate is a reversible voltage-gated sodium channel blocker. It blocks Nav1.7 currents in a concentration- and voltage-dependent manner (IC50s = 5.9 and 1.4 µM at holding potentials of -100 and -70 mV, respectively) and inhibits action potential firing in catecholamine A differentiated (CAD) cells. Benzonatate...
| Schlagworte: | 4-(butylamino)-benzoic acid, 3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yl ester |
| Anwendung: | Reversible voltage-gated sodium channel blocker |
| CAS | 104-31-4 |
| MW: | 603.8 D |
ab 67,00 €
Anti-SCN9A
Artikelnummer: E-AB-12861.120
This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. Protein function: Mediates the voltage-dependent...
| Schlagworte: | Anti-PN1, Anti-NENA, Anti-hNE-Na, Anti-Peripheral sodium channel 1, Anti-Neuroendocrine sodium channel, Anti-Sodium... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 89,00 €
Tolperisone (hydrochloride)
Artikelnummer: Cay26078-5
Tolperisone is a piperidine that acts as an inhibitor of voltage-gated sodium channels with an IC50 value of 198 µM, for inhibition of peak sodium currents evoked by step depolarizations in dorsal root ganglion (DRG) neurons, in vitro. Tolperisone acts as an antispastic agent that attenuates monosynaptic,...
| Schlagworte: | N-553, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone, monohydrochloride |
| Anwendung: | Voltage-gated sodium channel inhibitor, muscle relaxant |
| CAS | 3644-61-9 |
| MW: | 281.8 D |
ab 69,00 €
Ambroxol Hydrochloride
Artikelnummer: LKT-A4806.1
Expectorant.
| Schlagworte: | Abramen, Ambril, Duramucal, Fluibron, Fluixol, Mucolear, Mucosolvan, 4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-... |
| Anwendung: | Voltage-gated sodium channel (SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN8A, SCN9A) blocker |
| CAS | 23828-92-4 |
| MW: | 414.57 D |
ab 93,00 €