Zu "K04841" wurden 25 Artikel gefunden!
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GX-674
Artikelnummer: Cay39677-10
GX-674 is a state-dependent inhibitor of voltage-gated sodium channel 1.7 (Nav1.7). It selectively inhibits Nav1.7 in HEK293 cells in a patch-clamp assay at -40 mV over -120 mV, voltages that correspond to steady-state inactivation and the resting closed state of the channel (IC50s = 0.1 and 240 nM, respectively)....
| Schlagworte: | 4-[2-(2-amino-1H-benzimidazol-6-yl)-4-chlorophenoxy]-2,5-difluoro-N-1,2,4-thiadiazol-5-yl-benzenesulfonamide |
| Anwendung: | State-dependent Nav1.7 inhibitor |
| CAS | 1432913-36-4 |
| MW: | 534.9 D |
ab 62,00 €
Carbamazepine
Artikelnummer: Cay15422-5
Carbamazepine is an inhibitor of sodium channels. It preferentially inhibits inactivated voltage-gated sodium channel Nav1.7 and Nav1.3 (IC50s = 406 and 900 µM, respectively) over resting (closed) Nav1.7 and Nav1.3 channels in whole-cell patch-clamp assays using HEK293 cells (IC50s = 1,584 and 2,464 µM,...
| Schlagworte: | CBZ, NSC 169864, 5H-dibenz[b,f]azepine-5-carboxamide |
| Anwendung: | Voltage-gated sodium channel blocker |
| CAS | 298-46-4 |
| MW: | 236.3 D |
ab 35,00 €
Lacosamide-d3
Artikelnummer: Cay25426-500
Lacosamide-d3 (Cay-25426) is an analytical reference standard intended for use as an internal standard for the quantification of lacosamide by GC- or LC-MS. Lacosamide is categorized as an anticonvulsant. Formulations containing lacosamide have induced euphoria, auditory and visual hallucinations, and psychosis in...
| Schlagworte: | 2R-(acetylamino)-3-(methoxy-d3)-N-(phenylmethyl)-propanamide |
| Anwendung: | Analytical reference standard, GC-MS, LC-MS internal standard, Quantification, Anticonvulsant |
| CAS | 1217689-95-6 |
| MW: | 253.3 D |
ab 245,00 €
Bupivacaine
Artikelnummer: Cay16618-500
Bupivacaine is a sodium channel blocker and local anesthetic. It inhibits sodium currents in rat dorsal horn neurons in a concentration-dependent manner and inhibits synaptic transmission in rat sympathetic ganglia, increasing the firing threshold when used at a concentration of 200 nM. Bupivacaine (10 µM) blocks...
| Schlagworte: | 1-butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide |
| Anwendung: | Sodium influx blocker |
| CAS | 38396-39-3 |
| MW: | 288.4 D |
ab 43,00 €
NaV1.7 - HEK293 recombinant human stable cell line...
Artikelnummer: BPS-60507
Nav1.7 (Genbank # Q15858) is present at the endings of pain-sensing nerves, the nociceptors, close to region where the impulse is initiated. The Nav1.7 channel produces a rapidly activating and inactivating current which is sensitive to level of tetrodotoxin. Knockout mice that lack Nav1.7 in nociceptors showed...
| Schlagworte: | PN1, NENA, hNE-Na, Peripheral sodium channel 1, Neuroendocrine sodium channel, Sodium channel protein type 9 subunit... |
| Anwendung: | Drug screening, functional assays |
13.502,00 €
Anti-Nav1.7 Na+ Channel, clone S68-6
Artikelnummer: ARG56140.50
Protein function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical...
| Schlagworte: | Anti-PN1, Anti-NENA, Anti-hNE-Na, Anti-Peripheral sodium channel 1, Anti-Neuroendocrine sodium channel, Anti-Sodium... |
| Anwendung: | IHC (paraffin), WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | hamster, human, mouse, rat |
628,00 €
Anti-NAV1.7, clone S68-6
Artikelnummer: 200-301-G21
Anti-NAV1.7 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with NAV1.7 from Human, Rat, and Mouse based on 100% homology with the immunizing sequence. No cross-reactivity against other Nav channels. Cross-reactivity with NAV1.7 from other sources has not been...
| Schlagworte: | Anti-PN1, Anti-NENA, Anti-SCN9A, Anti-hNE-Na, Anti-Peripheral sodium channel 1, Anti-Neuroendocrine sodium channel,... |
| Anwendung: | IHC, IFM, IP, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
698,00 €
Anti-SCN9A
Artikelnummer: E-AB-16052.120
This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. Protein function: Mediates the voltage-dependent...
| Schlagworte: | Anti-PN1, Anti-NENA, Anti-hNE-Na, Anti-Peripheral sodium channel 1, Anti-Neuroendocrine sodium channel, Anti-Sodium... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 71,00 €
Benzonatate
Artikelnummer: Cay23936-1
Benzonatate is a reversible voltage-gated sodium channel blocker. It blocks Nav1.7 currents in a concentration- and voltage-dependent manner (IC50s = 5.9 and 1.4 µM at holding potentials of -100 and -70 mV, respectively) and inhibits action potential firing in catecholamine A differentiated (CAD) cells. Benzonatate...
| Schlagworte: | 4-(butylamino)-benzoic acid, 3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yl ester |
| Anwendung: | Reversible voltage-gated sodium channel blocker |
| CAS | 104-31-4 |
| MW: | 603.8 D |
ab 60,00 €
Anti-SCN9A
Artikelnummer: E-AB-12861.120
This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. Protein function: Mediates the voltage-dependent...
| Schlagworte: | Anti-PN1, Anti-NENA, Anti-hNE-Na, Anti-Peripheral sodium channel 1, Anti-Neuroendocrine sodium channel, Anti-Sodium... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 71,00 €
PF-05089771 (tosylate)
Artikelnummer: Cay24449-10
PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50s = 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8 channels (IC50s = 0.11-25 µM), L-type calcium, and KvLQT and hERG potassium channels (IC50s =...
| Schlagworte: | 4-[2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolyl-4-benzenesulfonamide,... |
| Anwendung: | Nav1.7 blocker |
| CAS | 1430806-04-4 |
| MW: | 672.6 D |
ab 131,00 €
Nav1.7 Blocker 52
Artikelnummer: Cay34477-10
Nav1.7 blocker 52 is an inhibitor of voltage-gated sodium channel 1.7 (Nav1.7, IC50 = 0.17 µM). It is selective for Nav1.7 over human-ether-a-go-go (hERG), also known as Kv11.1, Nav1.5, and Nav1.8 (IC50s = >10, 1.1, and 2.2 µM, respectively) but does inhibit Nav1.3 and Nav1.4 (IC50s = 0.3 and 0.4 µM, respectively)....
| Schlagworte: | TC-N 1752, Voltage-gated Sodium Channel 1.7,... |
| Anwendung: | Nav1.7 inhibitor |
| CAS | 1211866-85-1 |
| MW: | 516.5 D |
ab 163,00 €