GLPG1205

A GPR84 antagonist, inhibits DIM-induced GTPgammaS binding in cells overexpressing human GPR84 (IC50 = 54 nM), inhibits embelin-induced chemotaxis of isolated human neutrophils (IC50 = 11 nM), reduces body weight loss and rectal bleeding and improves stool consistency in a rat model of DSS-induced colitis. Formulation: A solid. InChI: InChI=1S/C22H22N2O4/c25-22-23-21(28-14-18-13-26-9-10-27-18)12-20-19-6-5-16(4-3-15-1-2-15)11-17(19)7-8-24(20)22/h5-6,11-12,15,18H,1-2,7-10,13-14H2/t18-/m0/s1. InChIKey: IRBAWVGZNJIROV-SFHVURJKSA-N. SMILES: O=C1N2C(C3=CC=C(C#CC4CC4)C=C3CC2)=CC(OC[C@@H]5COCCO5)=N1