Ginkgolide A

White powder. Soluble in DMSO (20mg/ml), DMF (20mg/ml) or ethanol (3mg/ml). Chemical. CAS: 15291-75-5. Formula: C20H24O9. MW: 408.40. Ginkgolide A is a terpenoid lactone originally isolated from G. biloba leaves. It shows diverse biological activities, including antioxidant, neuroprotective, anti-inflammatory and antiproliferative effects. Ginkgolide A inhibits platelet activating factor (PAF)-dependent aggregation of human platelets. It inhibits nitric oxide (NO) production. It also shows anxiolytic-like activity. It Inhibits NF-kappa activity by NF-kappa-specific suppressor IkappaBalpha. Ginkgolide A is a ligand of pregnane X receptor (PXR). It showed hepatoprotective efficacy by inducing cellular lipoapoptosis and by inhibiting cellular inflammation in NAFLD. Ginkgolide A reduced the proliferation rate of OVCA429 ovarian cancer cells by 40%.