Ginkgolide A

Ginkgolide A is a terpenoid lactone originally isolated from G. biloba leaves with diverse biological activities. Ginkgolide A inhibits platelet activating factor-dependent aggregation of human platelets (IC50 = 15.8 µg/ml). It also inhibits GABA-induced currents in Xenopus oocytes expressing human alpha1beta2gamma2L GABAA receptors with an IC50 value of 12 µM. Ginkgolide A (100 µM) reduces the proliferation rate of OVCA429 ovarian cancer cells by 40%. In vivo, ginkgolide A (1-2 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by 3-fold without altering activity level in mice, indicating anxiolytic-like activity. Ginkgolide A (10 mg/kg, p.o.) also reduces hexobarbital-induced sleeping time in mice by 44%. Ginkolide A (30 mg/kg per day) increases activity of the cytochrome P450 (CYP450) isoforms CYP1A2 and CYP2E1 by 1.82- and 1.27-fold, respectively, in rats.Formal Name: (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione. CAS Number: 15291-75-5. Synonyms: BN-52020. Molecular Formula: C20H24O9. Formula Weight: 408.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 3 mg/ml. lambdamax: 218 nm. SMILES: O=C(O1)[C@@H](C)[C@@]2(O)[C@]1([H])C[C@]34[C@@]25O[C@@]6([H])C3([C@@H](O)C(O6)=O)[C@H](C(C)(C)C)C[C@H]4OC5=O. InChi Code: InChI=1S/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3/t7-,8+,9-,10+,11+,15+,17-,18?,19-,20-/m1/s1. InChi Key: FPUXKXIZEIDQKW-XUYRAXNCSA-N. Origin: Plant/Ginkgo biloba L..