Gimeracil

White to yellow crystalline powder. Soluble in DMSO (25mg/ml) or DMF (20mg/ml). Chemical. CAS: 103766-25-2. Formula: C5H4ClNO2. MW: 145.54. Gimeracil is an orally active inhibitor against dihydropyrimidine dehydrogenase (DPYD), the rate limiting enzyme for the catabolism of pyrimidines, including the chemotherapeutic drug 5-fluorouracil (5FU). It has been administered concomitantly with 5-fluorouracil in a chemotherapy regimen termed S-1 to block 5-fluorouracil degradation, thus prolonging circulating 5-fluorouracil concentrations. Furthermore, Gimeracil has been shown to inhibit homologous recombination in the repair of DNA double strand breaks, which can sensitize cancer cells to radiotherapy.