GBR 12935 (hydrochloride)

GBR 12935 is an inhibitor of dopamine uptake that binds to the dopamine transporter (Kd = 27.2 nM). It is selective for the dopamine transporter over the serotonin and norepinephrine transporters (Kds = 940 and 310 nM, respectively). In mice, it increases locomotor activity, but not stereotypic behavior, when administered at a dose of 10 mg/kg but induces gnawing at levels similar to other indirect dopamine agonists with an ED50 value of 17.1 mg/kg.Formal Name: 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-piperazine, dihydrochloride. CAS Number: 67469-81-2. Molecular Formula: C28H34N2O . 2HCl. Formula Weight: 487.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 2 mg/ml. SMILES: C1(C(OCCN2CCN(CCCC3=CC=CC=C3)CC2)C4=CC=CC=C4)=CC=CC=C1.Cl.Cl. InChi Code: InChI=1S/C28H34N2O.2ClH/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27,,/h1-9,11-12,14-17,28H,10,13,18-24H2,2*1H. InChi Key: NQWRSILGEXNJIT-UHFFFAOYSA-N.