Ganoderic acid A

Description: 1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganoderic acid A can induce proliferation inhibition, apoptosis and suppression of invasion in human osteosarcoma HOS and MG-63 cells. 3. Ganoderic acid A promotes cisplatin-induced cell death by enhancing the sensitivity of HepG2 cells to cisplatin mainly via the signal transducer and activator of transcription 3 suppression, significantly suppresses IL-6-induced signal transducer and activator of transcription 3 phosphorylation. Target: Apoptosis, Autophagy, Endogenous Metabolite, NF-kappaB. Smiles: C[C@H](CC(=O)C[C@@H](C)C(O)=O)[C@H]1C[C@H](O)[C@@]2(C)C3=C(C(=O)C[C@]12C)[C@@]1(C)CCC(=O)C(C)(C)C1C[C@@H]3O. References: Shao J , Li Z , Jiao G , et al. [Ganoderic acid A suppresses proliferation and invasion and induces apoptosis in human osteosarcoma cells].[J]. Journal of Southern Medical University, 2015, 35(5):619.