Filaminast

A PDE4 inhibitor (IC50 = 0.42 µM), selective for PDE4 over PDE3 (IC50 = 15 µM) and a panel of receptors at 10 µM, induces relaxation in precontracted isolated guinea pig tracheal rings sensitized to PDE4 effects through PDE3 inhibition, induces bronchodilation in anesthetized bronchoconstriction-stabilized dogs (ED50 = 0.1mg/kg). SMILES: C/C(C1=CC(OC2CCCC2)=C(OC)C=C1)=N\OC(N)=O. InChi Code: InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)/b17-10+. InChi Key: STTRYQAGHGJXJJ-LICLKQGHSA-N