FIIN-3

Description: FIIN-3, an irreversible inhibitor of FGFR (Fibroblast Growth Factor Receptor), is a chemical compound designed to bind permanently to FGFR, thereby inhibiting its activity and potential downstream signaling pathways. Target: FGFR, EGFR. Smiles: COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccc(NC(=O)C=C)cc2)c2cc(Nc3ccc(cc3)N3CCN(C)CC3)ncn2)c1Cl. References: Tan L et al. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc Natl Acad Sci U S A, 2014 Nov 11, 111(45):E4869-77