Ferrichrome (iron-free)

Ferrichrome is a hydroxamate siderophore produced by various fungi, including U. sphaerogena, that facilitates iron chelation and uptake by these organisms. It can be utilized as a heterologous siderophore by bacteria, including P. aeruginosa and V. parahaemolyticus. Ferrichrome (0.8 µM) inhibits proliferation of murine spleen mononuclear cells induced by concanavalin A (Cay-14951) and reduces the number of concanavalin A-stimulated CD4+ T cells expressing the IL-2 receptor. It also inhibits heme-catalyzed oxidation of LDL by hydrogen peroxide in a concentration-dependent manner.Formal Name: cyclo(glycylglycylglycyl-N5-acetyl-N5-hydroxy-L-ornithyl-N5-acetyl-N5-hydroxy-L-ornithyl-N5-acetyl-N5-hydroxy-L-ornithyl). CAS Number: 34787-28-5. Synonyms: Desferrichrome. Molecular Formula: C27H45N9O12. Formula Weight: 687.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: 10 mg/ml. SMILES: O=C([C@H](CCCN(C(C)=O)O)NC([C@H](CCCN(C(C)=O)O)NC(CN1)=O)=O)N[C@@H](CCCN(C(C)=O)O)C(NCC(NCC1=O)=O)=O. InChi Code: InChI=1S/C27H45N9O12/c1-16(37)34(46)10-4-7-19-25(43)30-14-23(41)28-13-22(40)29-15-24(42)31-20(8-5-11-35(47)17(2)38)26(44)33-21(27(45)32-19)9-6-12-36(48)18(3)39/h19-21,46-48H,4-15H2,1-3H3,(H,28,41)(H,29,40)(H,30,43)(H,31,42)(H,32,45)(H,33,44)/t19-,20-. InChi Key: ZFDAUYPBCXMSBF-ACRUOGEOSA-N. Origin: Fungus/Ustilago sphaerogena.