Fendiline (hydrochloride)

Fendiline is an alpha2-adrenergic receptor antagonist (Kd = 2. µM) and an L-type calcium channel blocker (IC50 = 17 µM) well-known for its coronary vasodilator effects. Fendiline has recently been reported to inhibit K-Ras plasma membrane localization (IC50 = 9. µM), which prevents K-Ras signal transduction and blocks the proliferation of K-Ras-transformed tumor cells. InChI: InChI=1S/C23H25N.ClH/c1-19(20-11-5-2-6-12-20)24-18-17-23(21-13-7-3-8-14-21)22-15-9-4-10-16-22,/h2-16,19,23-24H,17-18H2,1H3,1H, InChIKey: NJXWZWXCHBNOOG-UHFFFAOYSA-N, SMILES: CC(C1=CC=CC=C1)NCCC(C2=CC=CC=C2)C3=CC=CC=C3.Cl