FEN1-IN-4

FEN1-IN-4 is an inhibitor of flap endonuclease 1 (FEN1, IC50 = 30 nM for FEN1-336Delta). It also inhibits exonuclease 1 in a concentration-dependent manner. FEN1-IN-4 (10 µM) inhibits ATP-induced mitochondrial DNA (mtDNA) fragmentation and levels of cytosolic mtDNA in LPS-primed primary mouse bone marrow-derived macrophages (BMDMs). It also inhibits ATP-induced phosphorylation of STING in LPS-primed wild-type and Nlrp3-/- primary mouse BMDMs. FEN1-IN-4 (40 mg/kg) decreases peritoneal levels of IL-1beta and neutrophil and monocyte infiltration in a mouse model of alum-induced peritonitis.Formal Name: 1-(cyclopropylmethyl)-3-hydroxy-2,4(1H,3H)-quinazolinedione. CAS Number: 1995893-58-7. Synonyms: FEN1 Inhibitor 4, Flap Endonuclease 1-IN-4, Flap Endonuclease 1 Inhibitor 4. Molecular Formula: C12H12N2O3. Formula Weight: 232.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: O=C1C2=C(N(CC3CC3)C(N1O)=O)C=CC=C2. InChi Code: InChI=1S/C12H12N2O3/c15-11-9-3-1-2-4-10(9)13(7-8-5-6-8)12(16)14(11)17/h1-4,8,17H,5-7H2. InChi Key: JAFLWTUYSKADJS-UHFFFAOYSA-N.