FEN1-IN-1

Description: FEN1-IN-1 (LNT-1) is an inhibitor of flap endonuclease 1 (FEN1). FEN1-IN-1 binds to the active site of FEN1. It partly achieves inhibition by the co-ordination of Mg2+ ions. Target: Others. Smiles: On1c(=O)n(CC2COc3ccccc3O2)c2ccsc2c1=O. References: Ward TA, et al. Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS One. 2017 Jun 19,12(6):e0179278.