FB23

FB23 is an inhibitor of the mRNA N6-methyladenosine (m6A) demethylase fat mass and obesity-associated (FTO) protein (IC50 = 0.06 µM) and an active metabolite of FB23-2 (Cay-36606). It reduces the proliferation of NB4 and Mono-Mac-6 acute myeloid leukemia (AML) cells (IC50s = 44.8 and 23.6 µM, respectively).Formal Name: 2-[[2,6-dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]-benzoic acid. CAS Number: 2243736-35-6. Molecular Formula: C18H14Cl2N2O3. Formula Weight: 377.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 2 mg/ml. lambdamax: 221 nm. SMILES: O=C(C1=C(NC2=C(C=C(C3=C(C)ON=C3C)C=C2Cl)Cl)C=CC=C1)O. InChi Code: InChI=1S/C18H14Cl2N2O3/c1-9-16(10(2)25-22-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(23)24/h3-8,21H,1-2H3,(H,23,24). InChi Key: VUXZATVQMFSUCM-UHFFFAOYSA-N.