Fasudil dihydrochloride

Description: Fasudil dihydrochloride, also known as HA-1077 and AT877, is a nonspecific inhibitor of RhoA/ROCK. It exhibits inhibitory effects on protein kinases, including ROCK1 with a Ki value of 0.33 µM, as well as ROCK2, PKA, PKC, and PKG with IC 50 values of 0.158 µM, 4.58 µM, 12.30 µM, and 1.650 µM, respectively. Additionally, Fasudil dihydrochloride demonstrates potent Ca 2+ channel blocking activity and acts as a vasodilator [1] [2] [3]. Target: Others. Smiles: Cl.Cl.O=S(=O)(N1CCCNCC1)c1cccc2cnccc12