EZM0414

Artikelnummer	Größe	Manual	Lieferzeit	Preis
Cay43914-1	1 mg	-	6 - 10 Werktage*	305,00 €
Cay43914-5	5 mg	-	6 - 10 Werktage*	912,00 €
Cay43914-10	10 mg	-	6 - 10 Werktage*	1.521,00 €
Cay43914-25	25 mg	-	6 - 10 Werktage*	2.660,00 €

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EZM0414 is an inhibitor of SET domain-containing protein 2 (SETD2, IC50 = 18 nM). It inhibits the... mehr

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Produktinformationen "EZM0414"

EZM0414 is an inhibitor of SET domain-containing protein 2 (SETD2, IC50 = 18 nM). It inhibits the proliferation of A549 non-small cell lung cancer (NSCLC) cells (EC50 = 57 nM). EZM0414 (15 and 30 mg/kg) decreases tumor volume in a KMS-11 multiple myeloma mouse xenograft model. It decreases cardiomyocyte levels of trimethylated lysine 36 on histone H3 (H3K36Me3) in a mouse model of heart failure with preserved ejection fraction (HFpEF) induced by a high-fat diet and L-NAME (Cay-80210). EZM0414 also reduces lung congestion and cardiac hypertrophy in the same model. InChI: InChI=1S/C22H29FN4O2/c1-14-6-7-19(23)18-13-20(25-21(14)18)22(29)24-16-4-3-5-17(12-16)27-10-8-26(9-11-27)15(2)28/h6-7,13,16-17,25H,3-5,8-12H2,1-2H3,(H,24,29)/t16-,17+/m1/s1, InChIKey: PGNLXEBQMQHFNK-SJORKVTESA-N, SMILES: FC1=C2C(NC(C(N[C@@H]3CCC[C@@H](C3)N4CCN(CC4)C(C)=O)=O)=C2)=C(C=C1)C

Schlagworte:	N-[(1R,3S)-3-(4-acetyl-1-piperazinyl)cyclohexyl]-4-fluoro-7-methyl-1H-indole-2-carboxamide
Hersteller:	Cayman Chemical
Hersteller-Nr:	43914

Eigenschaften

Anwendung:	SETD2 inhibitor
MW:	400.5 D
Formel:	C22H29FN4O2
Reinheit:	>98%
Format:	Solid

Datenbank Information

CAS :	2411748-50-8\| Passende Produkte
KEGG ID :	K11423 \| Passende Produkte

Handhabung & Sicherheit

Lagerung:	-20°C
Versand:	+20°C (International: -20°C)
Signalwort:	Warning
GHS-Piktogramme:
H-Sätze:	H315, H319, H335
P-Sätze:	P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501