Zu "K11423" wurden 24 Artikel gefunden!
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EZM0414
Artikelnummer: Cay43914-1
EZM0414 is an inhibitor of SET domain-containing protein 2 (SETD2, IC50 = 18 nM). It inhibits the proliferation of A549 non-small cell lung cancer (NSCLC) cells (EC50 = 57 nM). EZM0414 (15 and 30 mg/kg) decreases tumor volume in a KMS-11 multiple myeloma mouse xenograft model. It decreases cardiomyocyte levels of...
| Schlagworte: | N-[(1R,3S)-3-(4-acetyl-1-piperazinyl)cyclohexyl]-4-fluoro-7-methyl-1H-indole-2-carboxamide |
| Anwendung: | SETD2 inhibitor |
| CAS | 2411748-50-8 |
| MW: | 400.5 D |
ab 305,00 €
SetD2 Chemiluminescent Assay Kit
Artikelnummer: BPS-52060
The SETD2 Chemiluminescent Assay Kit is designed to measure SETD2 activity for screening and profiling applications. The SETD2 Chemiluminescent Assay Kit comes in a convenient strip format, with a 96-well plate precoated with histone H3 peptide substrate, the antibody against methylated lysine36 residue of Histone...
| Schlagworte: | SET Domain Containing 2, HYPB1, HIF-1, KMT3A, KIAA1732, SETD2, |
| Anwendung: | SETD2 activity screening |
1.182,00 €
SETD2, Active human recombinant protein, N-terminal GST-tag
Artikelnummer: BPS-53019
Human SETD2/pGEX6P1 (GenBank Accession No. NM_014159), amino acids 1418-1714, with N-terminal GST tag, MW= 60.9 kDa, expressed in an E.coli expression system.
| Schlagworte: | HIF-1, SETD2, HIP-1, hSET2, p231HBP, HSPC069, Huntingtin yeast partner B, Lysine N-methyltransferase 3A, SET... |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 60.9 kD |
663,00 €
Anti-SETD2
Artikelnummer: NSJ-R33954-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: SET domain containing 2 Protein function: Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate....
| Schlagworte: | Anti-HIF1, Anti-hSET2, Anti-SETD2, Anti-HIF-1, Anti-HIP-1, Anti-p231HBP, Anti-HSPC069, EC=2.1.1.43, Anti-Huntingtin yeast... |
| Anwendung: | WB, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human, mouse |
836,00 €
Anti-SETD2
Artikelnummer: E-AB-14627.120
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone...
| Schlagworte: | Anti-HIF-1, Anti-hSET2, Anti-SETD2, Anti-HIP-1, Anti-p231HBP, Anti-HSPC069, Anti-Huntingtin yeast partner B, Anti-Lysine... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 89,00 €
Anti-SETD2
Artikelnummer: E-AB-10851.120
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone...
| Schlagworte: | Anti-HIF-1, Anti-hSET2, Anti-SETD2, Anti-HIP-1, Anti-p231HBP, Anti-HSPC069, Anti-Huntingtin yeast partner B, Anti-Lysine... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 89,00 €
Anti-KMT3A / SETD2
Artikelnummer: ARG54749.100
Protein function: Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). Represents the main enzyme generating H3K36me3, a...
| Schlagworte: | Anti-HIP-1, Anti-hSET2, Anti-SETD2, Anti-HIF-1, Anti-p231HBP, Anti-HSPC069, Anti-Huntingtin yeast partner B, Anti-Lysine... |
| Anwendung: | IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
616,00 €
Anti-SETD2, clone CL9956
Artikelnummer: ATA-AMAb91603.100
Protein function: Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36...
| Schlagworte: | Anti-HIF-1, Anti-hSET2, Anti-SETD2, Anti-HIP-1, Anti-HSPC069, Anti-p231HBP, Anti-Huntingtin yeast partner B, Anti-Lysine... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 330,00 €
Anti-SETD2
Artikelnummer: ATA-HPA042451.100
Protein function: Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36...
| Schlagworte: | Anti-HIF-1, Anti-hSET2, Anti-SETD2, Anti-HIP-1, Anti-HSPC069, Anti-p231HBP, Anti-Huntingtin yeast partner B, Anti-Lysine... |
| Anwendung: | IHC, ICC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
ssK36 (trifluoroacetate salt)
Artikelnummer: Cay37514-1
ssK36 is a peptide super-substrate for the histone methyltransferase SET domain-containing protein 2 (SETD2) corresponding to amino acids 29-43 of histone H3 lysine 36 (H3K36) with amino acid substitutions at positions 31, 32, 36, 37, and 39. ssK36 is methylated 70-fold more and 290-fold faster than H3K36 (29-43) in...
| Schlagworte: | (S)-2-(((S)-2-((6S,9S,18S, 21S,24S)-1- amino-6-(((S)- 2-((S)-3- amino-2- oxobutanoyl) pyrrolidin-1- yl)amino)-21- (4-amino... |
| Anwendung: | SETD2 peptide super-substrate |
| MW: | 1771.1 D |
ab 76,00 €
Anti-SETD2
Artikelnummer: CSB-PA028785.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: SETD2. Antigen Species: Human
| Schlagworte: | Anti-HIP-1, Anti-HIF-1, Anti-SETD2, Anti-hSET2, Anti-HSPC069, Anti-p231HBP, Anti-Huntingtin yeast partner B, Anti-Lysine... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 167,00 €
Anti-SETD2
Artikelnummer: CSB-PA458397.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: SETD2. Antigen Species: Human
| Schlagworte: | Anti-HIP-1, Anti-HIF-1, Anti-SETD2, Anti-hSET2, Anti-HSPC069, Anti-p231HBP, Anti-Huntingtin yeast partner B, Anti-Lysine... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 167,00 €