EZH2-IN-15

Description: EZH2-IN-15 is a specific inhibitor of histone modifier enhancer of zeste 2 (EZH2). EZH2 is aberrantly overexpressed in a number of human cancers that controls the adaptive response via regulation of Treg activity. Intratumoral EZH2 expression has also been shown to control the innate immunity. Target: Histone Methyltransferase. Smiles: CCN(C1CCOCC1)c1cc2oc(CN3CCCCC3)cc2c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1CC. References: Zhang, Lan, et al. Use of ezh2 inhibitor combined with cdk4/6 inhibitor in preparation of drug for treating tumor. WO2021063332 A1