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NEU
Zeprumetostat
Artikelnummer: Cay44976-1
An EZH2 inhibitor (IC50 = 0.87 nM for the wild-type enzyme), selective for EZH2 over a panel of 24 histone and DNA methyltransferases (IC50s = >10,000 nM for all) but also inhibits EZH1 (IC50 = 19.1 nM), inhibits EZH2Y641C, EZH2Y641F, EZH2Y641N, EZH2Y641S, and EZH2Y641G (IC50s = 16.8, 2.68, 1.79, 5.07, and 1.13 nM,...
| Schlagworte: | SHR2554, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3- pyridinyl)methyl]-5-ethyl-6-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-... |
| Anwendung: | EZH2 inhibitor |
| CAS | 2098545-98-1 |
| MW: | 548.73 D |
ab 201,00 €
EZH2-IN-15
Artikelnummer: TGM-T67883-100mg
Description: EZH2-IN-15 is a specific inhibitor of histone modifier enhancer of zeste 2 (EZH2). EZH2 is aberrantly overexpressed in a number of human cancers that controls the adaptive response via regulation of Treg activity. Intratumoral EZH2 expression has also been shown to control the innate immunity. Target:...
| Schlagworte: | SHR2554 |
| CAS | 2098545-98-1 |
| MW: | 548.72 D |
ab 150,00 €
