Eurycomanone

Eurycomanone is a quassinoid originally isolated from E. longifolia that has diverse biological activities. It is active against the W2 and D6 clones of P. falciparum (IC50s = 0.015 and 0.026 µg/ml, respectively). Eurycomanone induces lipolysis in 3T3-L1 adipocytes with an EC50 value of 14.6 µM, an effect that can be blocked by the protein kinase A (PKA) inhibitor H-89 (Cay-10010556). It induces cell cycle arrest at the G2/M phase and apoptosis in HepG2 cells when used at a concentration of 5 µg/ml. It reduces estrogen release and increases testosterone release in isolated rat Leydig cell-rich testicular interstitial cell preparations when used at concentrations of 1 and 10 µM. Eurycomanone (1 mg/kg, i.p.) decreases gastric acid secretion and lesion size in rat models of indomethacin-, water immersion stress-, or pyloric ligation-induced ulcer formation.Formal Name: (1beta,11beta,12alpha,15beta)-11,20-epoxy-1,11,12,14,15-pentahydroxy-picrasa-3,13(21)-diene-2,16-dione. CAS Number: 84633-29-4. Synonyms: NSC 339187, Pasakbumin A. Molecular Formula: C20H24O9. Formula Weight: 408.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble. SMILES: C=C1[C@]([C@]([C@]2([H])[C@]3(O)[C@@H]1O)(CO3)[C@@](O4)([H])C[C@@]([C@]2(C)[C@@H]5O)([H])C(C)=CC5=O)(O)[C@@H](O)C4=O. InChi Code: InChI=1S/C20H24O9/c1-7-4-10(21)13(23)17(3)9(7)5-11-18-6-28-20(27,16(17)18)12(22)8(2)19(18,26)14(24)15(25)29-11/h4,9,11-14,16,22-24,26-27H,2,5-6H2,1,3H3/t9-,11+,12+,13+,14-,16+,17+,18+,19-,20-/m0/s1. InChi Key: UCUWZJWAQQRCOR-OKNZMGBLSA-N. Origin: Plant/Tongkat Ali.