Etoricoxib

Etoricoxib is a dipyridinyl compound that demonstrates high in vitro and ex vivo selectivity for COX-2 over COX-1 in several assays, e.g., in the production of PGE2 by CHO cells expressing either COX-2 (IC50 = 79 nM) or COX-1 (IC50 > 50 µM). Oral etoricoxib is well absorbed and metabolized extensively via oxidation, with metabolites excreted largely in the urine.Formal Name: 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine. CAS Number: 202409-33-4. Synonyms: L-791,456, MK-0663. Molecular Formula: C18H15ClN2O2S. Formula Weight: 358.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: freely, Methanol: freely. lambdamax: 236, 285 nm. SMILES: ClC1=CN=C(C2=CN=C(C)C=C2)C(C3=CC=C(S(C)(=O)=O)C=C3)=C1. InChi Code: InChI=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6-13)24(2,22)23/h3-11H,1-2H3. InChi Key: MNJVRJDLRVPLFE-UHFFFAOYSA-N.