Ethotoin

Ethotoin is a hydantoin anticonvulsant. It shortens the duration of the tonic extensor aspect of seizures induced by maximal electroshock in rats when administered at doses ranging from 500-1,000 mg/kg. It also decreases the duration of the tonic phase of seizures at a dose of 1,000 mg/kg but does not affect the duration of the clonic phase at any dose. Ethotoin (20 mg/kg, i.p.) decreases serum cholesterol and triglyceride concentrations in mice to 67 and 60%, respectively, of control after 16 days of treatment. Formulations containing ethotoin have been used in the treatment of tonic-clonic and complex partial seizures.Formal Name: 3-ethyl-5-phenyl-2,4-imidazolidinedione. CAS Number: 86-35-1. Synonyms: (±)-Ethotoin. Molecular Formula: C11H12N2O2. Formula Weight: 204.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble. SMILES: O=C(C(C1=CC=CC=C1)N2)N(CC)C2=O. InChi Code: InChI=1S/C11H12N2O2/c1-2-13-10(14)9(12-11(13)15)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H,12,15). InChi Key: SZQIFWWUIBRPBZ-UHFFFAOYSA-N.