(-)-Epicatechin

(-)-Epicatechin is a polyketide synthase-derived polyphenol flavonoid that has been found in T. cacao and has diverse biological activities. It scavenges DPPH (Cay-14805) radicals in a cell-free assay when used at a concentration of 5 µM. (-)-Epicatechin inhibits COX-1 (IC50 = 3.2 µM). It acts synergistically with epigallocatechin gallate (Cay-70935) to induce apoptosis in, and reduce the proliferation of, PC-9 lung cancer cells when used at a concentration of 200 µM. (-)-Epicatechin (80 mg/kg) reduces LPS-induced increases in plasma creatinine and urea levels in a rat model of renal inflammation.Formal Name: 2R-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3R,5,7-triol. CAS Number: 490-46-0. Synonyms: epi-Catechin, NSC 81161. Molecular Formula: C15H14O6. Formula Weight: 290.3. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 12.5 mg/ml, DMSO: 12.5 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 278 nm. SMILES: OC1=CC2=C(C[C@@H](O)[C@@H](C3=CC=C(O)C(O)=C3)O2)C(O)=C1. InChi Code: InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1. InChi Key: PFTAWBLQPZVEMU-UKRRQHHQSA-N. Origin: Plant/Acacia catechu.