Emraclidine

Artikelnummer	Größe	Manual	SDB	Lieferzeit	Preis
Cay42125-5	5 mg	-	-	6 - 10 Werktage*	557,00 €
Cay42125-10	10 mg	-	-	6 - 10 Werktage*	890,00 €
Cay42125-50	50 mg	-	-	6 - 10 Werktage*	1.391,00 €
Cay42125-100	100 mg	-	-	6 - 10 Werktage*	1.947,00 €

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An M4 muscarinic receptor PAM, selective for M4 mAChRs over a panel of 59 receptors, ion... mehr

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Produktinformationen "Emraclidine"

An M4 muscarinic receptor PAM, selective for M4 mAChRs over a panel of 59 receptors, ion channels, transporters, and enzymes at 10 µM, selectively potentiates ACh-induced activation of the M4 mAChR over M1-M3 and M5 mAChRs in cells expressing the human receptors (EC50s = 12.3, 4,798, >10,000, >10,000, and >10,000 nM, respectively), inhibits amphetamine-induced locomotor activity in mice and prepulse inhibition deficits in rats at 3.2 mg/kg. Formulation: A solid. InChI: InChI=1S/C20H21F3N4O/c1-12-5-13(2)25-17-11-27(10-16(12)17)19(28)6-14-8-26(9-14)15-3-4-24-18(7-15)20(21,22)23/h3-5,7,14H,6,8-11H2,1-2H3. InChIKey: DTCZNKWBDTXEBS-UHFFFAOYSA-N. SMILES: O=C(CC1CN(C1)C2=CC(C(F)(F)F)=NC=C2)N3CC4=NC(C)=CC(C)=C4C3

Schlagworte:	CVL-231, PF-06852231, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-2-[1-[2-(trifluoromethyl)-4-pyridinyl]-3-azetidinyl]-ethanone
Hersteller:	Cayman Chemical
Hersteller-Nr:	42125

Eigenschaften

Anwendung:	M4 muscarinic receptor positive allosteric modulator (PAM)
Immunogen:	390.4
MW:	390.4 D
Formel:	C20H21F3N4O
Reinheit:	>98%
Format:	Solid

Datenbank Information

CAS :	2170722-84-4\| Passende Produkte
KEGG ID :	K04132 \| Passende Produkte

Handhabung & Sicherheit

Lagerung:	-20°C
Versand:	+20°C (International: -20°C)
Signalwort:	Warning
GHS-Piktogramme:
H-Sätze:	H302, H315, H319, H335
P-Sätze:	P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501