Zu "K04132" wurden 43 Artikel gefunden!
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CHO-K1/M4/Galpha15 Stable Cell Line
Artikelnummer: GSC-M00238
Recombinant CHO-K1 cells stably overexpress human cholinergic receptor muscarinic 4 (M4) on the surface and contain high levels of G protein Galphai to couple with the receptor in downstream signaling pathways.
| Schlagworte: | CHRM4, Muscarinic acetylcholine receptor M4 |
11.424,00 €
Emraclidine
Artikelnummer: Cay42125-10
An M4 muscarinic receptor PAM, selective for M4 mAChRs over a panel of 59 receptors, ion channels, transporters, and enzymes at 10 µM, selectively potentiates ACh-induced activation of the M4 mAChR over M1-M3 and M5 mAChRs in cells expressing the human receptors (EC50s = 12.3, 4,798, >10,000, >10,000, and >10,000...
| Schlagworte: | CVL-231, PF-06852231,... |
| Anwendung: | M4 muscarinic receptor positive allosteric modulator (PAM) |
| CAS | 2170722-84-4 |
| MW: | 390.4 D |
ab 557,00 €
Methylatropine (nitrate)
Artikelnummer: Cay9002272-5
Methylatropine is an antagonist of muscarinic acetylcholine receptors (IC50 = 12008). It reduces acetylcholine-induced decreases in blood pressure in rats when administered intravenously with an ED50 value of 5.5 µg/kg. Methylatropine reduces salivation, induces mydriasis, and increases heart rate in dogs.Formal...
| Schlagworte: | Atropine methyl nitrate, (3-endo)- 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane, mononitrate |
| Anwendung: | Muscarinic acetylcholine antagonist |
| CAS | 52-88-0 |
| MW: | 366.4 D |
ab 102,00 €
Trospium (chloride)
Artikelnummer: Cay21279-50
Trospium is an antagonist of muscarinic (M) receptors (Kis = 0.50-2.3 nM for human M1-5 recombinant receptors, respectively). Formulations containing antimuscarinics, including trospium, are used to manage overactive bladder by relieving urgency, frequency, and incontinence.Formal Name:...
| Schlagworte: | Relaspium,... |
| Anwendung: | Muscarinic acetylcholine receptor antagonist |
| CAS | 10405-02-4 |
| MW: | 428 D |
ab 49,00 €
Scopolamine N-butylbromide
Artikelnummer: LKT-S1058.1
An antispasmodic agent.
| Schlagworte: | Butylscopolamine bromide |
| Anwendung: | Muscarinic cholinergic receptor antagonist |
| CAS | 149-64-4 |
| MW: | 440,38 D |
ab 100,00 €
Aclidinium (bromide)
Artikelnummer: Cay20699-5
Aclidinium is an antagonist of muscarinic acetylcholine receptors (mAChRs, Kis = 0.1, 0.14, 0.14, 0.21, and 0.16 for the M1-M5 receptors, respectively). It induces relaxation of precontracted isolated human bronchi when used at a concentration of 0.1 µM. Aclidinium reduces bronchoconstriction induced by ACh...
| Schlagworte: | LAS 34273, LAS-W 330, (3R)-3-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane,... |
| Anwendung: | mAChR antagonist |
| CAS | 320345-99-1 |
| MW: | 564.6 D |
ab 49,00 €
McNA343
Artikelnummer: Cay30961-10
McNA343 is a partial agonist of muscarinic acetylcholine receptors (Kis = 5, 1, 5, 0.2, and 7.6 µM for M1-5 receptors, respectively, in radioligand binding assays). It induces contraction of isolated human umbilical veins (EC50 = 1.23 µM), an effect that can be reversed by various M1 muscarinic receptor selective...
| Schlagworte: | 4-[[[(3-chlorophenyl)amino]carbonyl]oxy]-N,N,N-trimethyl-2-butyn-1-aminium, monochloride |
| Anwendung: | Muscarinic acetylcholine receptor partial agonist |
| CAS | 55-45-8 |
| MW: | 317.2 D |
ab 48,00 €
Bethanechol (chloride)
Artikelnummer: Cay23830-5
Bethanechol is an agonist of muscarinic acetylcholine receptors with IC50 values of 1,837, 25, 631, 317, and 393 µM for M1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors. It inhibits M2-mediated increases in cyclic AMP induced by isoproterenol (Cay-15592) in isolated...
| Schlagworte: | (±)-Bethanechol, Carbamyl-beta-methylcholine chloride, NSC 30783, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-1-propanaminium,... |
| Anwendung: | Muscarinic acetylcholine receptor agonist |
| CAS | 590-63-6 |
| MW: | 196.7 D |
ab 56,00 €
Oxybutynin (hydrochloride)
Artikelnummer: Cay23825-5
Oxybutynin is an antagonist of muscarinic acetylcholine receptors (Kis = 5, 14.5, 3.7, 5.3, and 40 nM for human recombinant M1-5, respectively). It inhibits intracellular calcium mobilization induced by carbamoylcholine (carbachol, Cay-14486) in bladder smooth muscle and submandibular gland cells isolated from...
| Schlagworte: | MJ4309-1, 4-(diethylamino)-2-butyn-1-yl ester alpha-cyclohexyl-alpha-hydroxy-benzeneacetic acid, monohydrochloride |
| Anwendung: | Muscarinic cholinergic receptor antagonist |
| CAS | 1508-65-2 |
| MW: | 394 D |
ab 110,00 €
Cyclopentolate (hydrochloride)
Artikelnummer: Cay23944-5
Cyclopentolate is an antagonist of muscarinic acetylcholine receptors (Kis = 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively). It inhibits carbachol-induced contraction of isolated human iris sphincter, circular ciliary muscle, and longitudinal ciliary muscle (Kbs = 7.9, 15.8, and 12.5 nM,...
| Schlagworte: | (±)-Cyclopentolate, alpha-(1-hydroxycyclopentyl)--benzeneacetic acid, 2-(dimethylamino)ethyl ester, monohydrochloride |
| Anwendung: | Muscarinic acetylcholine receptor antagonist |
| CAS | 5870-29-1 |
| MW: | 327.9 D |
ab 67,00 €
Tropicamide
Artikelnummer: Cay16606-1
Muscarinic receptors are G protein-coupled acetylcholine receptors that play diverse roles. Five subtypes (M1-5) have been identified, which preferentially couple to various effector systems based on their G protein interaction.Tropicamide is a muscarinic acetylcholine receptor (mAChR) antagonist (pKi = 7.2 in...
| Schlagworte: | Ro 1-7683, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-benzeneacetamide |
| Anwendung: | Muscarinic cholinergic receptor antagonist |
| CAS | 1508-75-4 |
| MW: | 284.4 D |
ab 49,00 €
Atropine
Artikelnummer: LKT-A7868.1
Atropine is a naturally occurring tropane alkaloid isolated from plants in the Solanaceae family. Atropine is an anticholinergic compound that also exhibits analgesic and antinociceptive activities. Atropine is a competitive inhibitor of muscarinic acetylcholine receptors (mAChRs) that is commonly used for...
| Anwendung: | Muscarinic cholinergic receptor antagonist |
| CAS | 51-55-8 |
| MW: | 289.37 D |
67,00 €