EMD534085

Description: EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM). Target: Kinesin. Smiles: [H][C@@]12CC[C@H](CNC(=O)NCCN(C)C)O[C@]1([H])c1cc(ccc1N[C@H]2c1ccccc1)C(F)(F)F. References: Schiemann K, et al. The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5. Bioorg Med Chem Lett. 2010 Mar 1,20(5):1491-5.