Eg5-I

The kinesin-like spindle protein Eg5, also known as KSP and Kif11, is a motor protein that is essential for establishing a bipolar spindle during mitosis. Eg5-I is a potent inhibitor of Eg5, both in vitro and in cells (IC50s = 127 and 190 nM, respectively). It is an analog of S-trityl-L-cysteine (STLC), but is more potent and has better solubility than STLC. Eg5-I blocks bipolar spindle formation and inhibits the growth of cancer cells, with an average GI50 value of 360 nM against a broad panel of tumor cells (GI50 range = 10 nM to 3 µM). It ranges from 140- to 1200-fold more potent against cancer cells than monastrol (Cay-15044), which also acts by inhibiting Eg5.Formal Name: (2R)-2-amino-3-[[(4-methoxyphenyl)diphenylmethyl]thio]-1-propanol. CAS Number: 1338701-15-7. Molecular Formula: C23H25NO2S. Formula Weight: 379.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 1 mg/ml. SMILES: OC[C@@H](N)CSC(C1=CC=C(OC)C=C1)(C2=CC=CC=C2)C3=CC=CC=C3. InChi Code: InChI=1S/C23H25NO2S/c1-26-22-14-12-20(13-15-22)23(27-17-21(24)16-25,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-15,21,25H,16-17,24H2,1H3/t21-/m1/s1. InChi Key: WKYHDWRETJHQFE-OAQYLSRUSA-N.