Zu "K10398" wurden 51 Artikel gefunden!
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Anti-KIF11 / Eg5
Artikelnummer: NSJ-F55018-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. KIF11 belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle...
| Schlagworte: | Anti-EG5, Anti-KIF11, Anti-TRIP-5, Anti-Kinesin-like protein 1, Anti-TR-interacting protein 5, Anti-Kinesin-like protein... |
| Anwendung: | FC, WB, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, hamster |
ab 326,00 €
Anti-KIF11 / Eg5
Artikelnummer: NSJ-RQ7230
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Kinesin-like protein KIF11, also called Kinesin-related motor protein Eg5, is a molecular motor protein that is essential in mitosis. In humans it is coded for by the gene KIF11. This gene encodes a motor protein that belongs to the kinesin-like protein family....
| Schlagworte: | Anti-EG5, Anti-KIF11, Anti-TRIP-5, Anti-Kinesin-like protein 1, Anti-TR-interacting protein 5, Anti-Kinesin-like protein... |
| Anwendung: | WB, IHC (paraffin), IF, FC, Direct ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
755,00 €
Monastrol
Artikelnummer: Cay15044-5
Monastrol is a reversible, cell-permeable inhibitor of the motor protein Eg5 (kinesin family protein 11, Kif11), blocking basal ATPase activity in vitro (IC50 = 6.1 µM) and inducing the formation of monoastral spindles in cell-based assays (IC50 = 51.3 µM). It arrests cells in mitosis without targeting tubulin and,...
| Schlagworte: | 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester |
| Anwendung: | Kinesin-like protein KIF11 / Eg5 inhibitor |
| CAS | 329689-23-8 |
| MW: | 292.4 D |
ab 92,00 €
S-trityl-L-Cysteine
Artikelnummer: Cay23236-1
S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. S-trityl-L-Cysteine inhibits the ATPase activity of Eg5 in basal and microtubule-stimulated states (IC50s = 1,000 and 140 nM, respectively). It is selective...
| Schlagworte: | NSC 83265, S-(triphenylmethyl)-L-cysteine |
| Anwendung: | Kif11 inhibitor |
| CAS | 2799-07-7 |
| MW: | 363.5 D |
ab 34,00 €
Anti-EG5/KIF11
Artikelnummer: A301-075A
Protein function: Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). [The UniProt Consortium]
| Schlagworte: | Anti-EG5, Anti-KIF11, Anti-TRIP-5, Anti-Kinesin-like protein 1, Anti-TR-interacting protein 5, Anti-Kinesin-like protein... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
S-Trityl-L-cysteine
Artikelnummer: LKT-T7232.5
S-Trityl-L-cysteine (STLC) is an organosulfur compound naturally produced in garlic plants. STLC exhibits anticancer and potential chemotherapeutic activities across several models. STLC acts as a mitotic inhibitor, inhibiting mitotic kinesin Eg5 and preventing separation of duplicated chromosomes and formation of...
| Schlagworte: | NSC83265 |
| Anwendung: | Kinesin Eg5 inhibitor |
| CAS | 2799-07-7 |
| MW: | 363.47 D |
ab 133,00 €
Ispinesib
Artikelnummer: Cay18014-5
The kinesin-like spindle protein Eg5 (also known as kinesin-5, kinesin family protein 11, or Kif11) is a motor protein that is essential for establishing a bipolar spindle during mitosis both in normal and tumor cells. Ispinesib is a cell-permeable, allosteric inhibitor of Eg5 (Ki app = 2.3 nM) with >10,000-fold...
| Schlagworte: | SB-715992,... |
| Anwendung: | Kinesin spindle protein (KSP/EG5 KIF11) inhibitor |
| CAS | 336113-53-2 |
| MW: | 517.1 D |
ab 60,00 €
Anti-EG5/KIF11
Artikelnummer: A301-076A-T
Protein function: Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). [The UniProt Consortium]
| Schlagworte: | Anti-EG5, Anti-KIF11, Anti-TRIP-5, Anti-Kinesin-like protein 1, Anti-TR-interacting protein 5, Anti-Kinesin-like protein... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
Monastrol
Artikelnummer: LKT-M5752.1
A cell-permeable small molecule inhibitor of the mitotic kinesin Eg5. It arrestscells in mitosis with monoastral spindles.
| Anwendung: | Eg5 inhibitor |
| CAS | 254753-54-3 |
| MW: | 292,35 D |
ab 117,00 €
Anti-Eg5, clone 4H3-1F12
Artikelnummer: ARG53992.100
Protein function: Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays. [The UniProt Consortium]
| Schlagworte: | Anti-EG5, Anti-KIF11, Anti-TRIP-5, Anti-Kinesin-like protein 1, Anti-TR-interacting protein 5, Anti-Kinesin-like protein... |
| Anwendung: | WB, IP, ICC, IF |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
624,00 €
K858
Artikelnummer: Cay22112-1
K858 is an inhibitor of kinesin spindle protein Eg5 (IC50 = 1.3 µM for Eg5 ATPase activity). It inhibits growth (GI50 = 0.98 µM), induces mitotic arrest (EC50 = 1.6 µM), and activates caspase-3 (EC50 = 1.6 µM) in HCT116 cells. It selectively induces mitotic cell death in HCT116 cells over non-cancerous ARPE-19...
| Schlagworte: | N-(4-acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)-acetamide |
| Anwendung: | KIF11 inhibitor |
| CAS | 72926-24-0 |
| MW: | 277.3 D |
ab 43,00 €
SB-743921 (hydrochloride)
Artikelnummer: Cay18384-1
SB-743921 is a potent inhibitor of the kinesin spindle protein Eg5 (Ki = 0.5 nM for microtubule-stimulated ATPase activity). It inhibits the growth of HCT116 colon, LNCaP and PC3 prostate, K562 leukemia, BxPC-3 pancreas, and NCI-H1299 lung cancer cell lines in vitro (GI50s = 25, 22, 48, 50, 80, and 82 nM,...
| Schlagworte: | N-(3-aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methyl-benzamide,... |
| Anwendung: | KIF11 inhibitor |
| CAS | 940929-33-9 |
| MW: | 553.5 D |
ab 60,00 €