Zu "K10398" wurden 81 Artikel gefunden!
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Monastrol
Artikelnummer: Cay15044-5
Monastrol is a reversible, cell-permeable inhibitor of the motor protein Eg5 (kinesin family protein 11, Kif11), blocking basal ATPase activity in vitro (IC50 = 6.1 µM) and inducing the formation of monoastral spindles in cell-based assays (IC50 = 51.3 µM). It arrests cells in mitosis without targeting tubulin and,...
| Schlagworte: | 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester |
| Anwendung: | Kinesin-like protein KIF11 / Eg5 inhibitor |
| CAS | 329689-23-8 |
| MW: | 292.4 D |
ab 102,00 €
S-trityl-L-Cysteine
Artikelnummer: Cay23236-1
S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. S-trityl-L-Cysteine inhibits the ATPase activity of Eg5 in basal and microtubule-stimulated states (IC50s = 1,000 and 140 nM, respectively). It is selective...
| Schlagworte: | NSC 83265, S-(triphenylmethyl)-L-cysteine |
| Anwendung: | Kif11 inhibitor |
| CAS | 2799-07-7 |
| MW: | 363.5 D |
ab 38,00 €
Anti-EG5/KIF11
Artikelnummer: A301-075A
Protein function: Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). [The UniProt Consortium]
| Schlagworte: | Anti-EG5, Anti-KIF11, Anti-TRIP-5, Anti-Kinesin-like protein 1, Anti-TR-interacting protein 5, Anti-Kinesin-like protein... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
S-Trityl-L-cysteine
Artikelnummer: LKT-T7232.5
S-Trityl-L-cysteine (STLC) is an organosulfur compound naturally produced in garlic plants. STLC exhibits anticancer and potential chemotherapeutic activities across several models. STLC acts as a mitotic inhibitor, inhibiting mitotic kinesin Eg5 and preventing separation of duplicated chromosomes and formation of...
| Schlagworte: | NSC83265 |
| Anwendung: | Kinesin Eg5 inhibitor |
| CAS | 2799-07-7 |
| MW: | 363.47 D |
ab 139,00 €
Ispinesib
Artikelnummer: Cay18014-5
Ispinesib is a cell-permeable, allosteric inhibitor of Eg5 (Ki app = 2. nM) with >10,000-fold selectivity for Eg5 over a range of other mitotic kinesins. It induces a monopolar spindle phenotype, leading to the activation of a spindle assembly checkpoint, mitotic arrest, and subsequent cell death (GI50s = 22-82 nM...
| Schlagworte: | SB-715992,... |
| Anwendung: | Kinesin spindle protein (KSP/EG5 KIF11) inhibitor |
| CAS | 336113-53-2 |
| MW: | 517.1 D |
ab 44,00 €
Anti-EG5/KIF11
Artikelnummer: A301-076A-T
Protein function: Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). [The UniProt Consortium]
| Schlagworte: | Anti-EG5, Anti-KIF11, Anti-TRIP-5, Anti-Kinesin-like protein 1, Anti-TR-interacting protein 5, Anti-Kinesin-like protein... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Dimethylenastron
Artikelnummer: Cay22357-1
Dimethylenastron is an inhibitor of the mitotic kinesin Eg5 (IC50 = 200 nM in an ATPase assay). It is selective for Eg5 over other kinesin subfamilies from four different organisms. Dimethylenastron induces accumulation of HeLa cells in the G2/M phase (75% at a concentration of 1 µM). It inhibits spindle formation...
| Schlagworte: | 2,3,4,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-5(1H)-quinazolinone |
| Anwendung: | KIF11 EG5 inhibitor |
| CAS | 863774-58-7 |
| MW: | 302.4 D |
ab 49,00 €
Monastrol
Artikelnummer: LKT-M5752.1
A cell-permeable small molecule inhibitor of the mitotic kinesin Eg5. It arrestscells in mitosis with monoastral spindles.
| Anwendung: | Eg5 inhibitor |
| CAS | 254753-54-3 |
| MW: | 292,35 D |
ab 124,00 €
Anti-Eg5, clone 4H3-1F12
Artikelnummer: ARG53992.100
Protein function: Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays. [The UniProt Consortium]
| Schlagworte: | Anti-EG5, Anti-KIF11, Anti-TRIP-5, Anti-Kinesin-like protein 1, Anti-TR-interacting protein 5, Anti-Kinesin-like protein... |
| Anwendung: | WB, IP, ICC, IF |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
658,00 €
K858
Artikelnummer: Cay22112-1
K858 is an inhibitor of kinesin spindle protein Eg5 (IC50 = 1.3 µM for Eg5 ATPase activity). It inhibits growth (GI50 = 0.98 µM), induces mitotic arrest (EC50 = 1.6 µM), and activates caspase-3 (EC50 = 1.6 µM) in HCT116 cells. It selectively induces mitotic cell death in HCT116 cells over non-cancerous ARPE-19...
| Schlagworte: | N-(4-acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)-acetamide |
| Anwendung: | KIF11 inhibitor |
| CAS | 72926-24-0 |
| MW: | 277.3 D |
ab 49,00 €
SB-743921 (hydrochloride)
Artikelnummer: Cay18384-1
SB-743921 is a potent inhibitor of the kinesin spindle protein Eg5 (Ki = 0.5 nM for microtubule-stimulated ATPase activity). It inhibits the growth of HCT116 colon, LNCaP and PC3 prostate, K562 leukemia, BxPC-3 pancreas, and NCI-H1299 lung cancer cell lines in vitro (GI50s = 25, 22, 48, 50, 80, and 82 nM,...
| Schlagworte: | N-(3-aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methyl-benzamide,... |
| Anwendung: | KIF11 inhibitor |
| CAS | 940929-33-9 |
| MW: | 553.5 D |
ab 58,00 €
Eg5-I
Artikelnummer: Cay16668-1
The kinesin-like spindle protein Eg5, also known as KSP and Kif11, is a motor protein that is essential for establishing a bipolar spindle during mitosis. Eg5-I is a potent inhibitor of Eg5, both in vitro and in cells (IC50s = 127 and 190 nM, respectively). It is an analog of S-trityl-L-cysteine (STLC), but is more...
| Schlagworte: | (2R)-2-amino-3-[[(4-methoxyphenyl)diphenylmethyl]thio]-1-propanol |
| Anwendung: | Eg5 inhibitor |
| CAS | 1338701-15-7 |
| MW: | 379.5 D |
ab 73,00 €