DuP-697

Description: DuP-697 is an irreversible and specific inhibitor of COX-2 with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1. DuP-697 shows antiproliferative activity with an IC50 of 42.8 nM. DuP-697 exhibits antiangiogenic, anti-inflammatory, antipyretic and apoptotic effects. Target: COX. Smiles: CS(=O)(=O)c1ccc(cc1)-c1cc(Br)sc1-c1ccc(F)cc1. References: Altun A, et al. Anticancer effect of COX-2 inhibitor DuP-697 alone and in combination with tyrosine kinase inhibitor (E7080) on colon cancer cell lines. Asian Pac J Cancer Prev. 2014,15(7):3113-21.