DS9300

DS9300 is an inhibitor of histone acetyltransferase p300 (IC50 = 28 nM). It inhibits acetylation of lysine 27 on histone H3 (H3K27) in LK-2 cells (IC50 = 54 nM). DS9300 inhibits the growth of VCaP prostate cancer cells (GI50 = 0.6 nM). In vivo, DS9300 (0.3-3 mg/kg) reduces tumor volume in a VCaP castrated mouse xenograft model. SMILES F[C@H]1CN(C(C2(CCC(F)(CC2)F)C3=CC=C(OC)C=C3)=O)[C@@H](C(NC4=CC=C5NN=CC5=N4)=O)C1 InChi Code InChI=1S/C25H26F3N5O3/c1-36-17-4-2-15(3-5-17)24(8-10-25(27,28)11-9-24)23(35)33-14-16(26)12-20(33)22(34)31-21-7-6-18-19(30-21)13-29-32-18/h2-7,13,16,20H,8-12,14H2,1H3,(H,29,32)(H,30,31,34)/t16-,20-/m1/s1