DREADD Agonist 21

DREADD agonist 21 activates hM3Dq (EC50 = 1.7 nM), a designer receptor exclusively activated by designer drugs (DREADD) derived from the human muscarinic acetylcholine M3 receptor. It does not agonize the hM3 receptor and displays relatively weaker binding affinities for serotonin 5-HT2A, 5-HT2C, alpha1A-adrenergic, and histamine H1 receptors (Kis = 66, 170, 280, and 6 nM, respectively).Formal Name: 11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine. CAS Number: 56296-18-5. Molecular Formula: C17H18N4. Formula Weight: 278.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 5 mg/ml. lambdamax: 224, 295 nm. SMILES: C1(C=CC=C2)=C2NC(C=CC=C3)=C3C(N4CCNCC4)=N1. InChi Code: InChI=1S/C17H18N4/c1-2-6-14-13(5-1)17(21-11-9-18-10-12-21)20-16-8-4-3-7-15(16)19-14/h1-8,18-19H,9-12H2. InChi Key: JCBYXNSOLUVGTF-UHFFFAOYSA-N.