DPTN (hydrochloride)

DPTN is an adenosine A3 receptor antagonist (Ki = 0.36 nM for the human receptor). It is selective for the adenosine A3 receptor over the adenosine A1 and A2A receptors (Kis = >666 and >826 nM, respectively). DPTN (10 mg/kg) prevents dye leakage in a rat model of plasma extravasation induced by the adenosine A3 receptor agonist IB-MECA (piclidenoson, Cay-28445). It, alone and in combination with the synthetic glucocorticoid dexamethasone (Cay-11015), inhibits airway hypersensitivity to acetylcholine in a rat model of allergen-induced asthma stimulated by ovalbumin inhalation when administered at a dose of 10 mg/kg.Formal Name: N-[4-(3,5-dimethylphenyl)-5-(4-pyridinyl)-2-thiazolyl]-3-pyridinecarboxamide, dihydrochloride. CAS Number: 325767-87-1. Molecular Formula: C22H18N4OS . 2HCl. Formula Weight: 459.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml. SMILES: O=C(C1=CN=CC=C1)NC2=NC(C3=CC(C)=CC(C)=C3)=C(C4=CC=NC=C4)S2.Cl.Cl. InChi Code: InChI=1S/C22H18N4OS.2ClH/c1-14-10-15(2)12-18(11-14)19-20(16-5-8-23-9-6-16)28-22(25-19)26-21(27)17-4-3-7-24-13-17,,/h3-13H,1-2H3,(H,25,26,27),2*1H. InChi Key: GTWKWBXTCBUKTR-UHFFFAOYSA-N.