DMP 543

DMP 543 is an inhibitor of the voltage-gated potassium channel Kv7.2 (IC50 = 0.048 µM) and a derivative of linopirdine (Cay-19547). It enhances potassium-induced acetylcholine (ACh) release in rat hippocampal slices (EC50 = 0.83 µM). DMP 543 (1 mg/kg) increases hippocampal extracellular ACh levels in rats.Formal Name: 10,10-bis[(2-fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone. CAS Number: 160588-45-4. Molecular Formula: C26H18F2N2O. Formula Weight: 412.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 30 mg/ml. SMILES: O=C1C2=C(C(CC3=CC=NC(F)=C3)(CC4=CC=NC(F)=C4)C5=C1C=CC=C5)C=CC=C2. InChi Code: InChI=1S/C26H18F2N2O/c27-23-13-17(9-11-29-23)15-26(16-18-10-12-30-24(28)14-18)21-7-3-1-5-19(21)25(31)20-6-2-4-8-22(20)26/h1-14H,15-16H2. InChi Key: MUJBUUDUXGDXLW-UHFFFAOYSA-N.