DL-Malic Acid

DL-Malic acid is the racemate of the metabolic intermediate L-malic acid. It reduces CCL2 and ICAM expression induced by IFN-gamma and TNF-alpha in HaCaT human keratinocytes when used at a concentration of 1 mM. Topical administration of DL-malic acid (10 mM) inhibits epidermis and dermis thickening, as well as mast cell and eosinophil dermal infiltration in a mouse model of atopic dermatitis induced by 2,4-dinitrochlorobenzene (DNBC). Formulations containing DL-malic acid have been used as food and cosmetic preservatives and acidity regulators.Formal Name: 2-hydroxy-butanedioic acid. CAS Number: 6915-15-7. Synonyms: E 296, Hydroxybutanedioic Acid, (±)-Malic Acid, NSC 25941, 2-hydroxy Succinic acid. Molecular Formula: C4H6O5. Formula Weight: 134.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(CC(C(O)=O)O)O. InChi Code: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9). InChi Key: BJEPYKJPYRNKOW-UHFFFAOYSA-N.