DL-AP5

DL-AP5 is the racemic version of the selective N-methyl-D-aspartate (NMDA) receptor antagonist, D-AP5 (Cay-14539). Whereas D-AP5 is the active (-)-stereoisomer that competitively inhibits the glutamate binding site of NMDA receptors (Kd = 1.4 µM), the (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity. AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.Formal Name: 5-phosphono-norvaline. CAS Number: 76326-31-3. Synonyms: DL-2-Amino-5-Phosphonovaleric acid, 2-APV. Molecular Formula: C5H12NO5P. Formula Weight: 197.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: OP(CCCC(C(O)=O)N)(O)=O. InChi Code: InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11). InChi Key: VOROEQBFPPIACJ-UHFFFAOYSA-N.