Dihydrotetrabenazine

Dihydrotetrabenazine is an active metabolite of the vesicular monoamine transporter 2 (VMAT2) inhibitor tetrabenazine (Cay-20380) that is generated by hepatic carbonyl reductases. Dihydrotetrabenazine binds to mouse pons medulla, hypothalamus, and striatum (Kds = 2.72, 2.28, and 2.4 nM, respectively) and inhibits synaptic vesicular serotonin (5-HT) uptake (IC50s = 2.2, 2.8, and 2.3 nM, respectively). It also binds to human caudate nucleus, hippocampus, and substantia nigra pars compacta (Kds = 2.9, 2.5, and 2.8 nM, respectively). Dihydrotetrabenazine stereoisomers bind to VMAT2 in rat striatum.Formal Name: 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol. CAS Number: 3466-75-9. Synonyms: DTBZ, trans-(2,3)-Dihydro Tetrabenazine. Molecular Formula: C19H29NO3. Formula Weight: 319.4. Purity: >98% (mixture of isomers). Formulation: (Request formulation change), A solid. Solubility: Chloroform: soluble, Methanol: soluble. SMILES: OC1C(CC(C)C)CN2C(C(C=C(OC)C(OC)=C3)=C3CC2)C1. InChi Code: InChI=1S/C19H29NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16-17,21H,5-7,10-11H2,1-4H3. InChi Key: WEQLWGNDNRARGE-UHFFFAOYSA-N.