Dihydroergocristine (mesylate)

Dihydroergocristine is an alkaloid with diverse biological activities. It inhibits contraction of isolated rat vas deferens induced by norepinephrine (pA2 = 7.88) but not calcium. Dihydroergocristine (0.1-100 µg/kg, i.v.) reduces blood pressure in a rat model of norepinephrine-induced hypertension and increases blood pressure in hypotensive rats. It reduces aqueous humor production and intraocular pressure in a rabbit model of alpha-chymotrypsin-induced ocular hypertension. Dihydroergocristine also reduces hypermotility induced by ethanol in mice.Formal Name: 9,10alpha-dihydro-12'-hydroxy-2'-(1-methylethyl)-5'alpha-(phenylmethyl)-ergotaman-3',6',18-trione, monomethanesulfonate. CAS Number: 24730-10-7. Molecular Formula: C35H41N5O5 . CH3SO3H. Formula Weight: 707.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: slightly soluble, Methanol: slightly soluble. SMILES: O=C([C@H]1CN(C)[C@@](CC2=CNC3=C2C4=CC=C3)([H])[C@]4([H])C1)N[C@]5(C(C)C)O[C@]([C@@](CCC6)([H])N6C([C@@H]7CC8=CC=CC=C8)=O)(O)N7C5=O.O=S(C)(O)=O. InChi Code: InChI=1S/C35H41N5O5.CH4O3S/c1-20(2)34(37-31(41)23-16-25-24-11-7-12-26-30(24)22(18-36-26)17-27(25)38(3)19-23)33(43)40-28(15-21-9-5-4-6-10-21)32(42)39-14-8-13-29(39)35(40,44)45-34,1-5(2,3)4/h4-7,9-12,18,20,23,25,27-29,36,44H,8,13-17,19H2,1-3H3,(H,37,41),1H3,(H,2,3,4)/t23-,25-,27-,28+,29+,34-,35+,/m1./s1. InChi Key: SPXACGZWWVIDGR-SPZWACKZSA-N.