Dihydrocytochalasin B

Dihydrocytochalasin B (DCB) is a member of the cytochalasin mycotoxin family that inhibits actin assembly. It blocks cleavage furrow formation and cytokinesis in synchronous HeLa cells at a concentration of 10 µM. DCB induces tetraploidy and arrests the cell cycle indefinitely in the G1 phase in REF-52 cells. It also increases the drug sensitivity of multidrug resistant SKVLB1 cells to paclitaxel (Cay-10461) and doxorubicin (Cay-15007) in vitro.Formal Name: (5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-4,5,6,7,8,9,10,12a,13,14,15,15a,16,17-tetradecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(3H)-dione. CAS Number: 39156-67-7. Synonyms: DCB. Molecular Formula: C29H39NO5. Formula Weight: 481.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:20): 0.05 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml. SMILES: O=C1CC[C@H](O)CCC[C@@H](C)C/C=C/[C@]([C@H](O)C([C@@H](C)[C@@]2([H])[C@H](CC3=CC=CC=C3)NC4=O)=C)([H])[C@@]24O1. InChi Code: InChI=1S/C29H39NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14,18-19,22-24,26-27,31,33H,3,7,9-10,13,15-17H2,1-2H3,(H,30,34)/b14-8+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1. InChi Key: WIULKAASLBZREV-RXPQEOCGSA-N.