Dihydrocapsiate

Light yellow liquid. Structurally related to capsaicin and found in the non-pungent pepper strain, CH-19 Sweet. Activates the transient receptor potential vanilloid 1 (TRPV1). Shown to have antioxidant, apoptosis incuding in tumor cell lines and anti-inflammatory activities. Inhibited vascular endothelial growth factor (VEGF)-induced proliferation, chemotactic motility, and capillary-like tube formation of primary cultured human endothelial cells. Stimulation of TRPV1 receptors in the gut are proposed to activate the SNS, which can increase lipogenesis and thermogenesis.