Zu "K05222" wurden 99 Artikel gefunden!
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Capsaicin
Artikelnummer: Cay92350-100
Capsaicin is a terpene alkaloid that has been found in Capsicum and has diverse biological activities. It induces inward currents in HEK293 cells expressing rat transient receptor potential vanilloid 1 (TRPV1, EC50 = 0.64 µM at neutral pH), an effect that can be blocked by the TRPV1 inhibitor A-425619. Capsaicin (10...
| Schlagworte: | N-[(4-hydroxy-3-methoxyphenyl)methyl]-6E-8-methyl-nonenamide |
| CAS | 404-86-4 |
| MW: | 305.4 D |
ab 128,00 €
Capsazepine
Artikelnummer: Cay10007518-1
Transient receptor potential vanilloid type 1 (TRPV1) is a member of the transient receptor potential (TRP) family that is activated or sensitized by a variety of endogenous stimuli as a result of tissue injury and inflammation. TRPV1 is upregulated during inflammation and plays a role in the perception of pain....
| Schlagworte: | N-[2-(4-chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide |
| Anwendung: | TRPV1 antagonist |
| CAS | 138977-28-3 |
| MW: | 376.9 D |
ab 49,00 €
BCTC
Artikelnummer: Cay10006309-5
The vanilloid receptor 1 (TRPV1) is a ligand-gated ion channel highly expressed on primary nociceptive neurons that respond to a variety of noxious stimuli, including heat, acid, and other chemical irritants. Because disruptions in TRPV1 activity cause reduced thermal nociception and hyperalgesia, this receptor is...
| Schlagworte: | 4-(3-chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide |
| Anwendung: | TRPV1 antagonist |
| CAS | 393514-24-4 |
| MW: | 372.9 D |
ab 62,00 €
Dihydrocapsaicin
Artikelnummer: Cay92355-5
Dihydrocapsaicin is a terpene alkaloid that has been found in Capsicum and has diverse biological activities. It is active against E. faecalis, B. subtilis, S. aureus, P. aeruginosa, K. pneumoniae, E. coli, and C. albicans (MICs = 0.6-10 µg/ml). Dihydrocapsaicin scavenges DPPH (Cay-14805) and ABTS (Cay-27317)...
| Schlagworte: | N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-nonanamide |
| CAS | 19408-84-5 |
| MW: | 307.4 D |
ab 49,00 €
Resiniferatoxin
Artikelnummer: TGM-T34295-1mg
Description: Resiniferatoxin ((+)-Resiniferatoxin) is a highly potent synthetic TRPV1 agonist that inhibits the production of Th1 cytokines and has anti-inflammatory activity, reducing serum levels of IL-12, INF-gamma, IL-1beta, TNF-alpha, NO, and PGE. Target: TRP/TRPV Channel, IL Receptor. Smiles:...
| Schlagworte: | RTX , [3H]resiniferatoxin |
| Anwendung: | Highly potent TRPV1 agonist |
| CAS | 57444-62-9 |
| MW: | 628.71 D |
ab 431,00 €
SB-366791
Artikelnummer: Cay11019-5
The transient receptor potential vanilloid type 1 (TRPV1) receptor is a nonselective cation channel gated by noxious heat, protons, and capsaicin. TRPV1 is present in primary sensory neurons and in both central and peripheral sensory nerve terminals and plays a role in thermal and mechanical hyperalgesia. SB-366791...
| Schlagworte: | 3-(4-chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide |
| Anwendung: | TRPV1 antagonist |
| CAS | 472981-92-3 |
| MW: | 287.7 D |
ab 53,00 €
Piperine
Artikelnummer: Cay11750-5
Piperine is a natural alkaloid that can be isolated from black pepper. It activates transient receptor potential vanilloid type 1 receptor (TRPV1, EC50 = 38 µM) and modulates GABAA receptors (EC50s = 43-60 µM). At similar levels, piperine inhibits both monoamine oxidases (MAOs), with IC50 values of 21 and 7 µM for...
| Schlagworte: | Bioperine, N-Piperoylpiperidin, NSC 21727, (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-(1-piperidinyl)-2,4-pentadien-1-one |
| Anwendung: | TRPV1 activator, MAO-A / MAO-B inhibitor |
| CAS | 94-62-2 |
| MW: | 285.3 D |
ab 45,00 €
Olvanil
Artikelnummer: Cay90262-50
Olvanil is a structural analog of capsaicin, which is the noxious active component of hot peppers of the Capsicum genus. It is the amide of vanillylamine and oleic acid. Olvanil acts as an agonist at the vanilloid receptor, VR1, inducing desensitization analgesia in rat and mouse models of pain. Olvanil has complex...
| Schlagworte: | N-Vanillyloleamide, NE 19550, N-[(4-hydroxy-3-methoxyphenyl)methyl]-9Z-octadecenamide |
| Anwendung: | Capsaicin analog |
| CAS | 58493-49-5 |
| MW: | 417.6 D |
ab 80,00 €
Nonivamide
Artikelnummer: Cay25328-1
Nonivamide is a transient receptor potential vanilloid type 1 (TRPV1) agonist and an analog of capsaicin (Cay-92350, Cay-10010743) that has been isolated from Capsicum species. It is toxic to NHBE, BEAS-2B, and BEAS-2B cells overexpressing TRPV1 (TRPV1-OE, LC50s = 160, 115, and 1 µM, respectively), increases calcium...
| Schlagworte: | Nonanoic Acid Vanillylamide, NSC 172795, N-Vanillylnonanamide, N-Vanillylpelargonamide, Pelargonic Acid Vanillylamide,... |
| Anwendung: | TRPV1 agonist |
| CAS | 2444-46-4 |
| MW: | 293.4 D |
ab 54,00 €
SB366791
Artikelnummer: AG-CR1-0034-M025
Potent and selective TRPV1 antagonist, Glutamatergic synaptic transmission inhibitor.
| Schlagworte: | N-(3-Methoxyphenyl)-4-chlorocinnamide |
| Anwendung: | TRPV1 antagonist |
| CAS | 472981-92-3 |
| MW: | 287,8 D |
ab 44,00 €
Vitexin
Artikelnummer: Cay15116-5
Vitexin is an apigenin flavone C-glycoside isolated from Crataegus spp. (hawthorn), Passiflora spp. (passionflower), P. glaucum R. Br. (pearl millet), P. nigra (bamboo leaves), V. agnuscastus L. (chasteberry), and various other tropical plant species. It demonstrates antioxidant activity in a DPPH bleaching assay...
| Schlagworte: | Orientoside, 8-beta-D-glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
| Anwendung: | Antioxidant |
| CAS | 3681-93-4 |
| MW: | 432.4 D |
ab 56,00 €
QX-314 (chloride)
Artikelnummer: Cay18454-50
QX-314 is a membrane-impermeant lidocaine derivative that selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, but is reportedly ineffective with extracellular application. When supplied in combination with 1 µM capsaicin (Cay-92350), a TRPV1 receptor...
| Schlagworte: | N-Ethyllidocaine, 2-[(2,6-dimethylphenyl)amino]-N,N,N-triethyl-2-oxo-ethanaminium, monochloride |
| Anwendung: | Sodium channel blocker |
| CAS | 5369-03-9 |
| MW: | 298.9 D |
181,00 €