Diffractaic Acid

Diffractaic acid is a lichen metabolite that has been found in P. magellanica and has diverse biological activities. It is cytotoxic to HCT116, HeLa, and MCF-7 cancer cells (IC50s = 42.2, 64.6, and 93.4 µM, respectively). Diffractaic acid inhibits growth of M. tuberculosis (MIC = 41.7 µM). In vivo, diffractaic acid (25-200 mg/kg) reduces neutrophil infiltration, lipid peroxidation, myeloperoxidase (MPx) activity, and the number of gastric lesions as well as reverses decreases in superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities induced by indomethacin (Cay-70270) in rat gastric mucosa. Diffractaic acid also has analgesic activity, reducing acetic acid-induced writhing and increasing the pressure pain threshold in mice.Formal Name: 2,4-dimethoxy-3,6-dimethyl-benzoic acid, 4-carboxy-3-hydroxy-2,5-dimethylphenyl ester. CAS Number: 436-32-8. Synonyms: NSC 5901, NSC 685595. Molecular Formula: C20H22O7. Formula Weight: 374.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O=C(O)C1=C(O)C(C)=C(OC(C2=C(OC)C(C)=C(OC)C=C2C)=O)C=C1C. InChi Code: InChI=1S/C20H22O7/c1-9-8-14(11(3)17(21)15(9)19(22)23)27-20(24)16-10(2)7-13(25-5)12(4)18(16)26-6/h7-8,21H,1-6H3,(H,22,23). InChi Key: MIJKZXWOOXIEEU-UHFFFAOYSA-N. Origin: Fungus/Cladia sp..