Diclofenac (sodium salt)

An NSAID and a COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 µM, for human COX-1 and COX-2, respectively), inhibits A23187-induced release of arachidonic acid in isolated rat peritoneal neutrophils and macrophages (IC50s = 60 and 10 µM, respectively), inhibits carrageenan-induced paw edema in rats. Formulation: A crystalline solid. InChI: InChI=1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19,/h1-7,17H,8H2,(H,18,19),/q,+1/p-1. InChIKey: KPHWPUGNDIVLNH-UHFFFAOYSA-M. SMILES: ClC1=C(N([H])C2=C(CC([O-])=O)C=CC=C2)C(Cl)=CC=C1.[Na+]