diABZI STING Agonist 3

diABZI STING agonist 3 is an agonist of stimulator of interferon genes (STING). It binds to STING (IC50 = 0.32 nM in a FRET assay) and induces STING transcriptional activity in a reporter assay (EC50 = 31.62 nM). diABZI STING agonist 3 increases protein levels of Nod-like receptor protein 3 (NLRP3), IL-1beta, and IL-18, but not cGAS or mtDNA, in macrophages.Formal Name: 1-[(2E)-4-[5-(aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-(3-hydroxypropoxy)-1H-benzimidazole-5-carboxamide. CAS Number: 2138299-29-1. Synonyms: CS-0029879, Diamidobenzimidazole Stimulator of Interferon Genes Agonist 3, Diamidobenzimidazole STING Agonist 3, diABZI STING Agonist 3, EX-A3217, HY-103665, Stimulator of Interferon Genes Agonist 3, STING Agonist 3. Molecular Formula: C37H42N12O6. Formula Weight: 750.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 40 mg/ml, sonicated. SMILES: NC(C1=CC=C(C(N=C2NC(C3=CC(C)=NN3CC)=O)=C1)N2C/C=C/CN4C5=C(OCCCO)C=C(C(N)=O)C=C5N=C4NC(C6=CC(C)=NN6CC)=O)=O. InChi Code: InChI=1S/C37H42N12O6/c1-5-48-28(16-21(3)44-48)34(53)42-36-40-25-18-23(32(38)51)10-11-27(25)46(36)12-7-8-13-47-31-26(19-24(33(39)52)20-30(31)55-15-9-14-50)41-37(47)43-35(54)29-17-22(4)45-49(29)6-2/h7-8,10-11,16-20,50H,5-6,9,12-15H2,1-4H3,(H2,38,51)(H2,39,52)(H,40,42,53)(H,41,43,54)/b8-7+. InChi Key: VHCDRDBBENBVEK-BQYQJAHWSA-N.