DG-172 (hydrochloride)

DG-172 is an orally available inverse agonist of PPARbeta/delta (IC50 = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC50 = 9.5 nM). It alters the differentiation of bone marrow cells, augmenting GM-CSF-induced development into subsets of mature and immature dendritic cells. Inverse agonists of PPARbeta/delta, including DG-172, inhibit cancer cell invasion through suppression of ANGPTL4 expression.Formal Name: 2-bromo-alphaZ-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]-benzeneacetonitrile, dihydrochloride. CAS Number: 1361504-77-9. Molecular Formula: C20H20BrN3 . 2HCl. Formula Weight: 455.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 25 mg/ml, Ethanol: 20 mg/ml. lambdamax: 241, 348 nm. SMILES: CN1CCN(C2=CC=C(/C=C(C#N)/C3=C(Br)C=CC=C3)C=C2)CC1.Cl.Cl. InChi Code: InChI=1S/C20H20BrN3.2ClH/c1-23-10-12-24(13-11-23)18-8-6-16(7-9-18)14-17(15-22)19-4-2-3-5-20(19)21,,/h2-9,14H,10-13H2,1H3,2*1H/b17-14+,,. InChi Key: SABUORLIDVBCPI-WTLOABTRSA-N.