Denecimig

Description: Denecimig (Mim8) is a bispecific and humanized IgG4kappa antibody mimicking activated coagulation factor VIII with anti-FIXa and anti-FX arms, which is used for the treatment of hemophilia A and coagulation disorders primarily by facilitating the assembly of activated coagulation factors IXa (FIXa) and X (FX) on platelet membranes, stimulating activation of FX, and arresting bleeding. Target: Factor VIII, Factor Xa. References: Lund J,et al.In vitro effects of combining Mim8 with factor VIII, FVIIa, and activated prothrombin complex concentrates in thrombin generation assays.J Thromb Haemost.2023 Jun,21(6):1493-1502.