DCPG

DCPG is a selective agonist of the class III metabotropic glutamate receptor 8 (mGluR8), with an EC50 value of 31 nM for inhibiting forskolin-stimulated cAMP formation in AV12-664 cells expressing human mGluR8. It is selective for mGluR8 over other mGluRs (EC50s = >3.5 µM for mGluR1-7). In vitro, DCPG (1 µM) inhibits the responses of mouse retinal ganglion cells to the withdrawal of both bright and dim light stimuli by 68-69% relative to untreated cells. In vivo, DCPG (10 nmol, i.c.v.) reverses catalepsy induced by prolonged exposure to haloperidol (Cay-12014) in a rat model of Parkinson's disease.Formal Name: 4-[(S)-aminocarboxymethyl]-1,2-benzenedicarboxylic acid. CAS Number: 201730-11-2. Synonyms: (S)-3,4-DCPG. Molecular Formula: C10H9NO6. Formula Weight: 239.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 20 mg/ml, Ethanol: 33 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(O)C1=C(C(O)=O)C=CC([C@H](N)C(O)=O)=C1. InChi Code: InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1. InChi Key: IJVMOGKBEVRBPP-ZETCQYMHSA-N.